Head Module Control of Mediator Interactions
نویسندگان
چکیده
منابع مشابه
Structure of the Mediator subunit Cyclin C and subunit interaction studies within the Mediator head module
Diese Dissertation wurde selbständig und ohne unerlaubte Hilfe erarbeitet. Acknowledgements I want to thank Patrick Cramer for everything that I learned during my PhD in his lab, especially for giving me the opportunity to work as independent as possible. are the four fellows who shared this whole time with me, I´m very glad that I met them and grateful for their understanding friendship. Sonja...
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The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for ...
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The successful synthesis of a transcript by RNA polymerase II (RNAPII) is a multistage process with distinct rate-limiting steps that can vary depending on the particular gene. A growing number of genes in a variety of organisms are regulated at steps after the recruitment of RNAPII. The best-characterized Saccharomyces cerevisiae gene regulated in this manner is CYC1. This gene has high occupa...
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Acknowledgements " Coming together is a beginning. Keeping together is progress. Working together is success. " This quote describes very well the multidisciplinary and collaborative atmosphere at the Gene Center in Munich. Therefore I am very glad to have decided to do my PhD thesis in the laboratory of Prof. Patrick Cramer. First of all, I would like to thank my supervisor Prof. Patrick Crame...
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The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps all protein-coding genes. Activator binding triggers major structural shifts within Mediator, suggesting a straightforward means to spatially and temporally regulate Mediator activity. By using mass spectrometry (MudPIT) and other techniques, we have compared the subunit composition of Mediator in three differ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2006
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2006.06.007